A research paper published on September 19 2012 in Food and Chemical Toxicology presents the results of the first animal feeding trial into the life-time exposure of Roundup tolerant GM corn and Roundup, the world’s best selling weed killer. It concludes that levels currently considered safe can cause mammary tumours, kidney and liver damage, in laboratory rats.
The study was led by molecular biologist and endocrinologist, Professor Gilles-Eric Seralini of the University of Caen in France and was supported by the independent research organization, CRIIGEN. The researchers used 200 rats that were fed a diet containing the Roundup tolerant GM maize, NK603, or given water containing Roundup, at levels permitted in drinking water and GM crops in the US. It showed that these rats developed tumours faster and died earlier than rats fed on a standard diet.
Citation: Séralini, G.-E., et al. Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize. Food Chem. Toxicol. (2012), http://dx.doi.org/10.1016/j.fct.2012.08.005
The health effects of a Roundup-tolerant genetically modified maize (from 11% in the diet), cultivated with or without Roundup, and Roundup alone (from 0.1 ppb in water), were studied 2 years in rats. In females, all treated groups died 2–3 times more than controls, and more rapidly. This difference was visible in 3 male groups fed GMOs. All results were hormone and sex dependent, and the pathological profiles were comparable. Females developed large mammary tumors almost always more often than and before controls, the pituitary was the second most disabled organ; the sex hormonal balance was modified by GMO and Roundup treatments. In treated males, liver congestions and necrosis were 2.5–5.5 times higher. This pathology was confirmed by optic and transmission electron microscopy. Marked and severe kidney nephropathies were also generally 1.3–2.3 greater. Males presented 4 times more large palpable tumors than controls which occurred up to 600 days earlier. Biochemistry data confirmed very significant kidney chronic deficiencies; for all treatments and both sexes, 76% of the altered parameters were kidney related. These results can be explained by the non linear endocrine-disrupting effects of Roundup, but also by the overexpression of the transgene in the GMO and its metabolic consequences.